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Hvordan fungerer cannabinoidplastre med hensyn til langvarig effekt sammenlignet med oral eller sublingual administration?

Hvordan fungerer cannabinoidplastre med hensyn til langvarig effekt sammenlignet med oral eller sublingual administration? Plastrene giver steady-state plasmaniveauer og undgår toppe og lavpunkter, der ses ved oral dosering. De omgår first-pass metabolisme, hvilket øger biotilgængeligheden sammenlignet med orale ruter. Sublingual administration giver hurtigere indtræden, men kortere varighed af virkninger. Patches er ideelle til vedvarende lindring, hvilket reducerer doseringsfrekvensen (Russo, 2011).

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