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Hvilke unikke udfordringer står forskerne over for, når de studerer cannabinoidernes langsigtede virkninger på mental sundhed? Forskere, der studerer de langsigtede virkninger af cannabinoider på mental sundhed, står over for udfordringer som at etablere passende undersøgelsesdesign, der tager højde for forvirrende variabler, herunder allerede eksisterende mentale helbredstilstande og samtidig stofbrug. Derudover kan det være vanskeligt at rekruttere en mangfoldig og repræsentativ prøve, da personer med visse sundhedsmæssige forhold kan være mindre tilbøjelige til at deltage i undersøgelser. Der er også mangel på standardiserede mål til vurdering af mentale sundhedsresultater, hvilket komplicerer datafortolkning og sammenligning på tværs af undersøgelser. Etiske bekymringer vedrørende de potentielle risici ved langvarig cannabinoidbrug kan hindre rekruttering og finansiering. For at løse disse udfordringer kan forskere anvende longitudinelle undersøgelser med omhyggelig deltagerovervågning og bruge validerede vurderingsværktøjer til at sikre robust dataindsamling (Wilkinson et al., 2020).
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