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Kako CBD i THC utječu na aktivnost enzima uključenih u metabolizam lijekova, posebno enzima CYP450 u jetri?

Kako CBD i THC utječu na aktivnost enzima uključenih u metabolizam lijekova, posebno enzima CYP450 u jetri? I CBD i THC inhibiraju enzime CYP450, mijenjajući metabolizam mnogih lijekova. Snažniji inhibicijski učinak CBD-a na CYP3A4 i CYP2C19 može produljiti djelovanje istodobno primijenjenih lijekova. THC također stupa u interakciju s CYP2C9, utječući na njegovu vlastitu razgradnju i pojačavajući njegove psihoaktivne učinke. Zajedno, oni zahtijevaju pažljivo prilagođavanje doze kada se koriste s drugim lijekovima kako bi se izbjegle interakcije. Ovo naglašava potrebu za kliničkim praćenjem u scenarijima polifarmacije.
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