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Kako se metabolizam THC-a razlikuje među pojedincima s različitim genetskim profilima, posebno CYP2C9 varijantama?

Kako se metabolizam THC-a razlikuje među pojedincima s različitim genetskim profilima, posebno CYP2C9 varijantama? Metabolizam THC-a značajno varira među pojedincima zbog razlika u enzimima citokroma P450, posebice CYP2C9, koji je prvenstveno odgovoran za oksidativni metabolizam THC-a. Ljudi s genetskim varijantama CYP2C9 (npr. CYP2C9*3) mogu sporije metabolizirati THC, što dovodi do viših koncentracija THC-a u krvi i potencijalno intenzivnijih ili produljenih psihoaktivnih učinaka. Nasuprot tome, pojedinci s učinkovitijim varijantama CYP2C9 mogu brže očistiti THC, što rezultira manje intenzivnim povišenjem. Ove genetske razlike također mogu utjecati na to kako pojedinci reagiraju na medicinski kanabis, utječući i na terapijsku učinkovitost i na rizik od štetnih učinaka. Personalizirano doziranje i genetsko testiranje mogu pomoći u prilagođavanju terapije kanabinoidima pojedinačnim metaboličkim profilima.

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