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Kako THC i CBD međusobno djeluju kako bi utjecali na ekspresiju gena u stanicama raka?

Kako THC i CBD međusobno djeluju kako bi utjecali na ekspresiju gena u stanicama raka? THC i CBD međusobno djeluju na složene načine kako bi utjecali na ekspresiju gena u stanicama raka. THC, kao djelomični agonist CB1 i CB2 receptora, može pospješiti staničnu smrt (apoptozu) i smanjiti staničnu proliferaciju u određenim stanicama raka, često putem aktivacije putova poput p53. CBD, nasuprot tome, djeluje tako da inhibira rast tumorskih stanica putem CB2 receptora i mehanizama neovisnih o p53, uključujući regulaciju autofagije i smanjenje migracije stanica. U kombinaciji, THC i CBD mogu sinergistički utjecati na ekspresiju gena, pojačavajući apoptozu i smanjujući metastaze kod nekih vrsta raka. Ova kombinacija je obećavajuća za terapiju raka, budući da može pružiti učinkovitiju strategiju za smanjenje rasta tumora i poboljšanje odgovora na liječenje.

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