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Koje su strukturne razlike između THC-a i drugih kanabinoida koje ga čine psihoaktivnim?

Koje su strukturne razlike između THC-a i drugih kanabinoida koje ga čine psihoaktivnim? Psihoaktivni učinci THC-a proizlaze iz njegove sposobnosti da veže i aktivira CB1 receptore u mozgu, što drugi kanabinoidi poput CBD-a ne čine tako učinkovito. Ključna strukturna razlika je u tome što THC ima tetrahidrokanabinolnu skupinu koja mu omogućuje da se učinkovitije uklopi u vezni džep CB1 receptora, što dovodi do veće aktivacije receptora. Nasuprot tome, CBD i drugi kanabinoidi, poput CBC ili CBG, nemaju isti afinitet za CB1 receptore i mogu čak djelovati kao antagonisti ili modulatori učinaka THC-a. Psihoaktivna priroda THC-a stoga je povezana s ovim specifičnim afinitetom vezanja i konformacijskim promjenama na razini receptora. Ova je razlika temeljna u određivanju psihoaktivnih svojstava THC-a u usporedbi s nepsihoaktivnim kanabinoidima.

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