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Che ruolo svolgono gli enzimi cutanei nel metabolizzare i cannabinoidi dai cerotti transdermici?

Che ruolo svolgono gli enzimi cutanei nel metabolizzare i cannabinoidi dai cerotti transdermici? Gli enzimi della pelle, in particolare quelli presenti nell'epidermide, possono metabolizzare i cannabinoidi man mano che vengono assorbiti, influenzandone potenzialmente la biodisponibilità e gli effetti terapeutici. Enzimi come il citocromo P450 svolgono un ruolo nella scomposizione dei cannabinoidi prima che entrino nel flusso sanguigno, il che potrebbe ridurne l'efficacia se non tenuto in considerazione. La formulazione del cerotto può essere progettata per bypassare questi enzimi prendendo di mira gli strati più profondi della pelle o includere inibitori per modulare l'attività enzimatica, garantendo che siano disponibili più cannabinoidi per l'azione sistemica.

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