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Come si confrontano i cerotti ai cannabinoidi con altre forme di somministrazione a rilascio prolungato in termini di biodisponibilità e durata dell'effetto?

Come si confrontano i cerotti ai cannabinoidi con altre forme di somministrazione a rilascio prolungato in termini di biodisponibilità e durata dell'effetto? I cerotti ai cannabinoidi forniscono un rilascio costante e costante di cannabinoidi per un periodo prolungato, garantendo effetti terapeutici prolungati. Altre forme a rilascio prolungato, come compresse orali o spray sublinguali, possono subire ritardi nell’insorgenza e un assorbimento variabile a causa dell’effetto di primo passaggio o della variabilità gastrointestinale. I cerotti offrono un assorbimento più prevedibile e localizzato, riducendo le fluttuazioni sistemiche. Il loro design consente una durata d’azione più lunga, rendendoli preferibili per condizioni che richiedono un dosaggio continuo (Baswan et al., 2020).

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