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In che modo i diversi livelli di pH della pelle influiscono sull’efficacia dei cannabinoidi nei cerotti transdermici?

In che modo i diversi livelli di pH della pelle influiscono sull’efficacia dei cannabinoidi nei cerotti transdermici? Le variazioni del pH della pelle influenzano la solubilità e la permeabilità dei cannabinoidi attraverso l’epidermide. Gli ambienti acidi della pelle possono accelerare la degradazione dei cannabinoidi, influenzandone la stabilità. Le formulazioni devono mantenere un equilibrio del pH compatibile con la barriera naturale della pelle. Gli agenti tamponanti possono aiutare a stabilizzare il rilascio di cannabinoidi a diversi livelli di pH (Patel et al., 2020).

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