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Qual è il ruolo del sistema endocannabinoide nella gestione del dolore?

Qual è il ruolo del sistema endocannabinoide nella gestione del dolore? Il sistema endocannabinoide svolge un ruolo cruciale nella gestione del dolore, regolandone la percezione e la risposta attraverso i recettori CB1 e CB2. I recettori CB1, localizzati nel cervello e nel sistema nervoso centrale, contribuiscono a modulare i segnali del dolore riducendo il rilascio di neurotrasmettitori eccitatori. I recettori CB2, presenti principalmente nei tessuti periferici, influenzano l'infiammazione, spesso associata al dolore. Gli endocannabinoidi, come l'anandamide e il 2-AG, vengono prodotti dall'organismo in risposta a lesioni o infiammazioni, legandosi a questi recettori per alleviare il disagio. La regolazione del dolore da parte del sistema endocannabinoide è essenziale per il mantenimento dell'omeostasi e la gestione delle condizioni di dolore cronico.
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