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How can the concentration gradient between the patch and skin improve or hinder cannabinoid diffusion through the skin?

How can the concentration gradient between the patch and skin improve or hinder cannabinoid diffusion through the skin? The concentration gradient between the patch and the skin is critical for the diffusion of cannabinoids. A higher concentration of cannabinoids in the patch compared to the skin drives the diffusion process, enhancing absorption. However, if the gradient is too steep, rapid diffusion may lead to high initial doses that the skin may not absorb efficiently. Conversely, a weaker gradient may result in slower absorption, reducing the therapeutic effectiveness. Proper formulation and patch design help manage this gradient for optimal cannabinoid delivery.

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