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How do cannabinoid molecules interact with skin proteins like keratin to enhance or inhibit their delivery via transdermal patches?

How do cannabinoid molecules interact with skin proteins like keratin to enhance or inhibit their delivery via transdermal patches? Cannabinoid molecules, which are lipophilic, interact with skin proteins like keratin to enhance or inhibit their delivery through the skin. Keratin, found in the epidermis, can act as a barrier, slowing down the penetration of cannabinoids. However, cannabinoids may also interact with skin lipids, helping them pass through the outermost layers of the skin. Enhancing the penetration of cannabinoids often involves modifying the patch formulation to include penetration enhancers that temporarily disrupt the keratin structure, allowing for better absorption.

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