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How does the combination of CBD and THC in edibles affect their onset and duration of effects compared to smoking or vaping cannabis?

How does the combination of CBD and THC in edibles affect their onset and duration of effects compared to smoking or vaping cannabis? The combination of CBD and THC in edibles results in a slower onset and longer duration of effects compared to smoking or vaping. When consumed orally, the cannabinoids pass through the digestive system and liver, where THC is metabolized into 11-hydroxy-THC, a more potent form that prolongs the effects. This process leads to delayed effects, typically taking 30 minutes to 2 hours to feel full results. The effects from edibles last longer, often several hours, compared to smoking or vaping, which delivers cannabinoids directly into the bloodstream for a faster but shorter-lasting effect. This difference provides sustained relief, especially for conditions requiring long-term symptom management.
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