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Hvordan modulerer CBD og THC døgngenekspression i hjernen og leveren, og hvilken indflydelse har dette på søvn-vågen-cyklusser?

Hvordan modulerer CBD og THC døgngenekspression i hjernen og leveren, og hvilken indflydelse har dette på søvn-vågen-cyklusser? CBD og THC påvirker døgnrytmer ved at interagere med cannabinoidreceptorer i hjerneområder som den suprachiasmatiske kerne. THC fremmer søvnbegyndelse ved at aktivere CB1-receptorer, mens CBD øger vågenhed og regulerer døgngenekspression i leveren. Denne kombination hjælper med at genoprette forstyrrede søvn-vågne-cyklusser under tilstande som søvnløshed. CBD's virkninger på serotoninreceptorer forbedrer også søvnkvaliteten. Sammen giver de en afbalanceret tilgang til døgnregulering.
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