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Kako CBD utječe na sposobnost THC-a da modulira sinaptički prijenos u prefrontalnom korteksu?

Kako CBD utječe na sposobnost THC-a da modulira sinaptički prijenos u prefrontalnom korteksu? CBD utječe na učinak THC-a na sinaptički prijenos u prefrontalnom korteksu modulirajući aktivnost CB1 receptora. THC, aktiviranjem CB1 receptora u prefrontalnom korteksu, može narušiti sinaptički prijenos, što dovodi do kognitivnih nedostataka, uključujući poremećeno donošenje odluka i radnu memoriju. CBD, međutim, djeluje kao modulator, smanjujući prekomjernu aktivaciju CB1 receptora THC-om i tako štiteći sinaptičku funkciju. Ova interakcija može očuvati kognitivnu izvedbu, omogućujući terapeutske učinke kao što su regulacija raspoloženja i anksiolitički učinci bez pogoršanja kognitivnog oštećenja. U kombinaciji, CBD pomaže stabilizirati učinke THC-a, potencijalno povećavajući terapeutske prednosti dok minimalizira kognitivne nuspojave.

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