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Come si confrontano i cerotti ai cannabinoidi con altri metodi di somministrazione come le tinture sublinguali in termini di insorgenza e durata degli effetti?

Come si confrontano i cerotti ai cannabinoidi con altri metodi di somministrazione come le tinture sublinguali in termini di insorgenza e durata degli effetti? I cerotti transdermici forniscono un'azione più lenta ma una durata prolungata rispetto alle tinture sublinguali, che agiscono rapidamente ma hanno effetti più brevi. I cerotti mantengono livelli plasmatici stabili nel tempo, riducendo le fluttuazioni dell’effetto terapeutico. A differenza della somministrazione sublinguale, i cerotti bypassano il metabolismo di primo passaggio, migliorando la biodisponibilità. La scelta tra i metodi dipende dalla velocità desiderata e dalla consistenza degli effetti dei cannabinoidi (Zgair et al., 2016).

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