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In che modo CBD e THC influiscono sull'espressione dei geni coinvolti nella regolazione del dolore nei pazienti con dolore cronico?

In che modo CBD e THC influiscono sull'espressione dei geni coinvolti nella regolazione del dolore nei pazienti con dolore cronico? CBD e THC influiscono sull'espressione genetica correlata alla regolazione del dolore modulando il sistema endocannabinoide e influenzando fattori di trascrizione come NF-κB. Il THC attiva direttamente i recettori CB1 e CB2, che possono sottoregolare i geni coinvolti nella percezione del dolore e nell’infiammazione. Il CBD supporta questo processo inibendo enzimi come FAAH, che aumentano i livelli di endocannabinoidi, e modulando i recettori TRPV1 legati alla segnalazione del dolore. Insieme, alterano l’espressione delle citochine proinfiammatorie e dei percorsi correlati al dolore, riducendo il dolore cronico. Questa sinergia porta ad un sollievo dal dolore più efficace e mirato nei pazienti con patologie croniche.
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