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In che modo le variazioni di temperatura possono influenzare l’assorbimento dei cannabinoidi dai cerotti transdermici?

In che modo le variazioni di temperatura possono influenzare l’assorbimento dei cannabinoidi dai cerotti transdermici? Le variazioni di temperatura possono influenzare la permeabilità della pelle, che a sua volta influenza l’assorbimento dei cannabinoidi dai cerotti transdermici. Temperature più elevate aumentano il flusso sanguigno e la permeabilità della pelle, migliorando potenzialmente l’assorbimento dei cannabinoidi, mentre temperature più basse possono rallentare l’assorbimento. La formulazione del cerotto può essere regolata per garantire una distribuzione costante a temperature variabili utilizzando vettori sensibili alla temperatura o incorporando sistemi a rilascio controllato. Garantire che il cerotto mantenga prestazioni stabili in caso di temperature fluttuanti può migliorarne l’efficacia complessiva.

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