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In che modo l'elasticità della pelle influenza il tasso di assorbimento dei cannabinoidi a chiazze, soprattutto nelle popolazioni più anziane?

In che modo l'elasticità della pelle influenza il tasso di assorbimento dei cannabinoidi a chiazze, soprattutto nelle popolazioni più anziane? La ridotta elasticità della pelle nelle popolazioni che invecchiano può influenzare l’adesione dei cerotti e la diffusione dei farmaci. Una pelle più sottile e meno idratata può alterare i tassi di assorbimento, portando potenzialmente a una maggiore biodisponibilità. La formulazione di cerotti con adesivi flessibili garantisce un rilascio uniforme del farmaco in diverse condizioni cutanee. Gli eccipienti idratanti migliorano l'integrità della pelle e ottimizzano l'assorbimento negli anziani (Baswan et al., 2020).

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