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In che modo l'elasticità della pelle influisce sull'assorbimento e sul rilascio dei cannabinoidi quando applicati tramite cerotti transdermici?

In che modo l'elasticità della pelle influisce sull'assorbimento e sul rilascio dei cannabinoidi quando applicati tramite cerotti transdermici? L’elasticità della pelle influisce sull’assorbimento e sul rilascio dei cannabinoidi nei cerotti transdermici influenzando la capacità di adesione del cerotto e la distribuzione uniforme dei cannabinoidi. Nelle aree con maggiore elasticità cutanea, come la pelle più giovane o le regioni più flessibili come l'interno del braccio, il cerotto può adattarsi meglio alla superficie della pelle, favorendo un assorbimento costante. Al contrario, una pelle meno elastica o invecchiata può avere difficoltà a mantenere l’adesione del cerotto o un efficiente rilascio di cannabinoidi. In questi casi, modificare la forza adesiva del cerotto o incorporare ulteriori agenti condizionanti la pelle può migliorare sia l'adesione che l'assorbimento.

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