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In che modo lo stress meccanico applicato a un cerotto transdermico durante l'uso (ad esempio, stiramento o flessione) influenza il rilascio di cannabinoidi?

In che modo lo stress meccanico applicato a un cerotto transdermico durante l'uso (ad esempio, stiramento o flessione) influenza il rilascio di cannabinoidi? Lo stress meccanico, come lo stiramento o la flessione, può alterare le prestazioni dei cerotti transdermici influenzandone l'adesione e la velocità di rilascio. La deformazione del cerotto può aumentare la superficie a contatto con la pelle, accelerando potenzialmente il rilascio di cannabinoidi. Al contrario, lo stress può anche danneggiare il materiale del cerotto, provocando un rilascio irregolare o disagio. Per mitigare questi effetti, i cerotti possono essere progettati con materiali flessibili che mantengono l'adesione e il rilascio controllato anche sotto stress meccanico.

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