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Qual è il ruolo dell’espressione dei recettori dei cannabinoidi sulla pelle nell’efficacia della veicolazione transdermica dei cannabinoidi?

Qual è il ruolo dell’espressione dei recettori dei cannabinoidi sulla pelle nell’efficacia della veicolazione transdermica dei cannabinoidi? I recettori dei cannabinoidi, principalmente CB1 e CB2, sono espressi nelle cellule della pelle e svolgono un ruolo cruciale nel modulare gli effetti dei cannabinoidi. I recettori CB1, presenti nelle terminazioni nervose e nelle cellule della pelle, influenzano sensazioni come dolore e prurito, mentre i recettori CB2 modulano l’infiammazione e le risposte immunitarie. La presenza e la distribuzione di questi recettori possono influenzare il modo in cui i cannabinoidi vengono metabolizzati e il loro impatto terapeutico quando applicati localmente. Una maggiore espressione dei recettori in determinate condizioni della pelle può aumentare l’efficacia della somministrazione transdermica di cannabinoidi.

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