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How do CBD and THC influence pain signaling pathways through the CB1 and CB2 receptors in the endocannabinoid system?

How do CBD and THC influence pain signaling pathways through the CB1 and CB2 receptors in the endocannabinoid system? CBD and THC modulate pain through CB1 and CB2 receptors by altering pain transmission pathways. THC binds to CB1 receptors in the brain and spinal cord, inhibiting pain signals and providing immediate analgesia. CBD works by modulating CB2 receptors in peripheral tissues, reducing inflammation and enhancing the body’s natural pain management. Together, they interact with the body’s endocannabinoid system to regulate pain perception and reduce the intensity of chronic pain. Their combined effect offers a comprehensive approach to pain management.
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