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How does skin hydration impact the permeability of cannabinoids in transdermal patches, and how can this be controlled?

How does skin hydration impact the permeability of cannabinoids in transdermal patches, and how can this be controlled? Skin hydration plays a significant role in cannabinoid permeability by affecting the skin's barrier function. Well-hydrated skin has a thinner, more flexible barrier, which facilitates the absorption of cannabinoids. Dehydrated skin, on the other hand, may impede cannabinoid penetration. To control hydration, formulations can include humectants such as glycerin or hyaluronic acid, and users can be encouraged to hydrate their skin before patch application to improve the effectiveness of cannabinoid delivery.

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