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How does the bioavailability of THC vary with different administration routes, and what implications does this have for patient care?

How does the bioavailability of THC vary with different administration routes, and what implications does this have for patient care? The bioavailability of THC varies significantly depending on the administration route, influencing its therapeutic effects and patient care. For instance, inhalation methods (e.g., smoking or vaping) provide rapid onset and high bioavailability (around 30-50%), allowing for quick relief of symptoms. Conversely, oral administration results in lower bioavailability (around 4-12%) due to first-pass metabolism in the liver, leading to delayed effects. This variability necessitates personalized dosing strategies for patients, as the route of administration can significantly impact the efficacy and safety profile of THC. Understanding these differences is crucial for healthcare providers when recommending cannabis-based therapies (Huestis, 2007).
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