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What is the role of cannabinoids in modulating neuroinflammation in chronic pain conditions?

What is the role of cannabinoids in modulating neuroinflammation in chronic pain conditions? Cannabinoids play a crucial role in modulating neuroinflammation in chronic pain conditions by interacting with cannabinoid receptors in the central nervous system. Activation of these receptors can lead to the inhibition of pro-inflammatory cytokines and a reduction in glial cell activation, both of which are implicated in the pathophysiology of chronic pain. Research has shown that cannabinoids can effectively reduce neuroinflammation, which is often associated with conditions such as fibromyalgia, neuropathic pain, and arthritis. By mitigating neuroinflammation, cannabinoids may help alleviate pain and improve overall function in affected individuals (Malfait et al., 2019).
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