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Hoe verbetert de combinatie van CBD en THC de behandeling van chronische migraine door neurovasculaire ontstekingen te beïnvloeden?

Hoe verbetert de combinatie van CBD en THC de behandeling van chronische migraine door neurovasculaire ontstekingen te beïnvloeden? CBD en THC verminderen neurovasculaire ontstekingen door het endocannabinoïdesysteem en andere signaalroutes die betrokken zijn bij de pathofysiologie van migraine te moduleren. THC bindt zich aan CB1-receptoren, waardoor de afgifte van neuropeptiden zoals CGRP, die bijdragen aan migrainepijn en -ontsteking, wordt verminderd. CBD vult dit aan door oxidatieve stress te verminderen en TRPV1-receptoren te moduleren, die betrokken zijn bij pijnsignalering. Samen verminderen ze de frequentie en intensiteit van migraine door zowel ontstekings- als vasculaire componenten aan te pakken. Deze combinatie biedt een veelzijdige aanpak voor de behandeling van chronische migraine.
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