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Hvordan påvirker hudens alder og elasticitet absorptionen af cannabinoider gennem depotplastre?

Hvordan påvirker hudens alder og elasticitet absorptionen af ​​cannabinoider gennem depotplastre? Ældre hud har reduceret lipidindhold og tyndere epidermale lag, hvilket kan forbedre cannabinoidpermeabiliteten, men reducere hydreringsafhængig absorption. Tab af elasticitet kan ændre plasterets vedhæftning, hvilket påvirker dosiskonsistensen. Yngre, mere hydreret hud kan understøtte bedre cannabinoidopløselighed, men langsommere penetration. Plasterformuleringer skal tage højde for aldersrelaterede hudændringer for at sikre ensartet effekt på tværs af forskellige populationer (Benson, 2005).

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