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Koji su kombinirani učinci THC-a i CBD-a na stres endoplazmatskog retikuluma u neuronima?

Koji su kombinirani učinci THC-a i CBD-a na stres endoplazmatskog retikuluma u neuronima? Kombinirani učinci THC-a i CBD-a na stres endoplazmatskog retikuluma (ER) u neuronima mogu varirati ovisno o doziranju i kontekstu. THC može izazvati ER stres putem aktivacije CB1 receptora, što dovodi do poremećaja u savijanju proteina i neurodegeneraciji. Međutim, pokazalo se da CBD smanjuje ER stres promicanjem stanične homeostaze i aktiviranjem zaštitnih putova, kao što je autofagija. Kada se koristi zajedno, CBD može ublažiti negativne učinke THC-a na zdravlje neurona vraćanjem funkcije ER, što ovu kombinaciju čini potencijalno korisnom kod neurodegenerativnih bolesti. Stoga bi ravnoteža između ovih kanabinoida mogla utjecati na terapijsku primjenu za neurodegenerativna stanja koja uključuju ER stres.

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