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Come si confronta l’uso di un cerotto transdermico con il tradizionale consumo orale di cannabinoidi per alleviare il dolore cronico?

Come si confronta l’uso di un cerotto transdermico con il tradizionale consumo orale di cannabinoidi per alleviare il dolore cronico? I cerotti transdermici forniscono un rilascio più costante e controllato di cannabinoidi rispetto al consumo orale, evitando il metabolismo di primo passaggio che avviene nel fegato. Ciò si traduce in una maggiore biodisponibilità, poiché i cannabinoidi vengono assorbiti direttamente nel flusso sanguigno attraverso la pelle. Il consumo orale, d'altro canto, porta a tassi di assorbimento variabili a causa di fattori digestivi e può richiedere più tempo per produrre effetti. I cerotti transdermici offrono un sollievo mirato, che può essere utile per il dolore cronico localizzato.

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