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Come si può modificare la struttura chimica dei cannabinoidi per migliorarne la diffusione e l'assorbimento attraverso la pelle?

Come si può modificare la struttura chimica dei cannabinoidi per migliorarne la diffusione e l'assorbimento attraverso la pelle? La struttura chimica dei cannabinoidi può essere modificata per migliorare la permeabilità della pelle alterandone la polarità, le dimensioni o la solubilità. Ad esempio, ridurre il peso molecolare o aumentare la lipofilia dei cannabinoidi può aiutarli a penetrare nella pelle in modo più efficace. Anche la modifica dei gruppi funzionali o l’uso di profarmaci (forme inattive che diventano attive una volta assorbite) possono migliorare l’assorbimento. Queste modifiche garantiscono che i cannabinoidi passino attraverso la barriera cutanea in modo più efficiente, fornendo un sollievo terapeutico più rapido ed efficace.

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