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In che modo le molecole di cannabinoidi interagiscono con le proteine della pelle come la cheratina per migliorare o inibire il loro rilascio tramite cerotti transdermici?

In che modo le molecole di cannabinoidi interagiscono con le proteine ​​della pelle come la cheratina per migliorare o inibire il loro rilascio tramite cerotti transdermici? Le molecole di cannabinoidi, che sono lipofile, interagiscono con le proteine ​​della pelle come la cheratina per migliorare o inibire il loro rilascio attraverso la pelle. La cheratina, presente nell'epidermide, può fungere da barriera, rallentando la penetrazione dei cannabinoidi. Tuttavia, i cannabinoidi possono anche interagire con i lipidi cutanei, aiutandoli a passare attraverso gli strati più esterni della pelle. Migliorare la penetrazione dei cannabinoidi spesso comporta la modifica della formulazione del cerotto per includere potenziatori della penetrazione che interrompono temporaneamente la struttura della cheratina, consentendo un migliore assorbimento.

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