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¿Cómo afectan el CBD y el THC a la expresión genética relacionada con la neuroinflamación y sus implicaciones terapéuticas para la enfermedad de Alzheimer?

¿Cómo afectan el CBD y el THC a la expresión genética relacionada con la neuroinflamación y sus implicaciones terapéuticas para la enfermedad de Alzheimer? El CBD y el THC alteran la expresión de genes implicados en vías inflamatorias y neuroprotectoras, incluida la señalización NF-kB y Nrf2. El CBD regula negativamente los genes asociados con las citocinas proinflamatorias, mientras que el THC activa los receptores CB2 para suprimir la sobreactivación microglial. Esta modulación combinada reduce la neuroinflamación, un sello distintivo de la enfermedad de Alzheimer. Sus efectos reguladores de genes también mejoran las defensas antioxidantes, frenando el daño neuronal. Estas acciones apoyan el desarrollo de terapias basadas en cannabis para el Alzheimer.
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