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How can multi-layer transdermal patches be designed to release cannabinoids at different rates over time?

How can multi-layer transdermal patches be designed to release cannabinoids at different rates over time? Multi-layer transdermal patches can be designed with different cannabinoid-containing layers that dissolve or release cannabinoids at varying rates. The layers can be formulated with different excipients, such as lipophilic or hydrophilic carriers, to create differential release profiles. Some layers may release cannabinoids immediately for fast relief, while others release more slowly for prolonged therapeutic effects. This design can be further optimized by incorporating rate-limiting membranes or polymer matrices to control the release of each layer independently.

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