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How do CBD and THC affect the metabolism of other medications taken concurrently in medical cannabis treatments?

How do CBD and THC affect the metabolism of other medications taken concurrently in medical cannabis treatments? CBD and THC can alter the metabolism of other medications by interacting with liver enzymes, particularly the cytochrome P450 enzyme system. CBD inhibits certain cytochrome P450 enzymes, which can slow down the metabolism of drugs that rely on these enzymes for clearance, potentially increasing their levels in the blood. THC may also affect enzyme activity but typically has a less pronounced effect than CBD. Patients taking medications alongside cannabis should be monitored for changes in drug efficacy or side effects, as the altered metabolism can impact the effectiveness of other treatments. This interaction is important for adjusting doses of concurrent medications to avoid toxicity or therapeutic failure.
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