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How do the relative polarities of cannabinoids like CBG, CBN, and CBD affect their skin absorption rates when delivered via patches?

How do the relative polarities of cannabinoids like CBG, CBN, and CBD affect their skin absorption rates when delivered via patches? The relative polarities of cannabinoids affect their ability to diffuse through the skin's lipid-rich layers. Cannabinoids with higher polarity, such as CBD, may have slower absorption rates because they are less soluble in lipids, which form the skin's barrier. Less-polar cannabinoids like CBG and CBN may be absorbed more readily, as they are better able to dissolve in the skin’s lipids. The polarity of cannabinoids must be considered when formulating transdermal patches to optimize absorption and therapeutic effect.

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