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Kako THC utječe na sinaptičko orezivanje tijekom kritičnih razdoblja razvoja mozga?

Kako THC utječe na sinaptičko orezivanje tijekom kritičnih razdoblja razvoja mozga? Izloženost THC-u tijekom kritičnih razdoblja razvoja mozga može poremetiti sinaptičko obrezivanje, proces u kojem se eliminiraju suvišne neuronske veze radi učinkovitijeg rada mozga. Interagirajući s CB1 receptorima na neuronima u razvoju, THC može narušiti normalnu ravnotežu sinaptičkog jačanja i slabljenja, što je bitno za pravilno kognitivno sazrijevanje. Ovaj poremećaj može dovesti do dugotrajnih učinaka na učenje i izvršnu funkciju. Osobito u adolescenciji, upotreba THC-a može rezultirati smanjenim volumenom sive tvari i promijenjenim moždanim vezama. Ovi učinci mogu povećati osjetljivost na psihijatrijske poremećaje, uključujući shizofreniju i kognitivni pad kasnije u životu.

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