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In che modo il pH della pelle influenza la solubilità e l'assorbimento dei cannabinoidi nei cerotti transdermici?

In che modo il pH della pelle influenza la solubilità e l'assorbimento dei cannabinoidi nei cerotti transdermici? Il pH della pelle, leggermente acido (intorno a 4,5–5,5), influenza la solubilità dei cannabinoidi, soprattutto quelli lipofili come il CBD. Quando il pH della pelle è troppo alto o troppo basso, può alterare la solubilità dei cannabinoidi, riducendone potenzialmente l'efficienza di assorbimento. Garantire che il pH della formulazione del cerotto corrisponda al pH naturale della pelle aiuta a ottimizzare la solubilità e la permeabilità dei cannabinoidi, migliorandone la veicolazione. Questo equilibrio migliora sia il tasso

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