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In che modo il THC influenza i sistemi serotoninergici e noradrenergici nel cervello?

In che modo il THC influenza i sistemi serotoninergici e noradrenergici nel cervello? Il THC agisce sul sistema serotoninergico legandosi ai recettori 5-HT, in particolare al recettore 5-HT1A, che può influenzare l'umore e l'ansia. Il THC può aumentare il rilascio di serotonina, contribuendo a creare sensazioni di euforia, ma in alcuni casi può portare ad ansia o paranoia a causa delle alterazioni dei livelli di serotonina. Inoltre, il THC interagisce con il sistema noradrenergico, influenzando il rilascio di norepinefrina, che influenza la vigilanza, le risposte allo stress e la funzione cognitiva. Queste interazioni svolgono un ruolo nel modulare l’umore e le risposte allo stress durante il consumo di cannabis. L’equilibrio tra questi sistemi può aiutare a spiegare perché alcuni utenti sperimentano sollievo dall’ansia mentre altri segnalano effetti negativi come un aumento della paranoia.

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