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¿Cómo afectan el CBD y el THC a la actividad de las células microgliales en condiciones neurodegenerativas, particularmente en la enfermedad de Alzheimer y Parkinson?

¿Cómo afectan el CBD y el THC a la actividad de las células microgliales en condiciones neurodegenerativas, particularmente en la enfermedad de Alzheimer y Parkinson? El CBD y el THC reducen la neuroinflamación al modular la actividad de las células microgliales, las células inmunitarias del cerebro. El CBD suprime la liberación de citoquinas proinflamatorias y promueve un cambio hacia un estado microglial antiinflamatorio, mientras que la interacción del THC con los receptores CB2 amortigua aún más la activación microglial. Esta doble acción protege a las neuronas del daño oxidativo y del estrés inflamatorio, retardando la progresión de enfermedades neurodegenerativas como el Alzheimer y el Parkinson. Juntos, promueven un entorno neuroprotector al reducir la sobreactivación microglial crónica. Esta sinergia respalda mejores resultados en estas enfermedades.
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