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¿Cómo funcionan sinérgicamente el CBD y el THC para modular la percepción del dolor en pacientes con fibromialgia y síndromes de dolor crónico?

¿Cómo funcionan sinérgicamente el CBD y el THC para modular la percepción del dolor en pacientes con fibromialgia y síndromes de dolor crónico? El CBD y el THC modulan la percepción del dolor activando los receptores CB1 y CB2 en los sistemas nerviosos central y periférico. El THC proporciona efectos analgésicos inmediatos al unirse a los receptores CB1, mientras que el CBD modula la inflamación y la señalización del dolor a través de mecanismos independientes y dependientes de los receptores. Su acción combinada reduce la intensidad del dolor y mejora el umbral general del dolor. Además, el CBD potencia los efectos analgésicos del THC minimizando su impacto psicoactivo. Juntos, proporcionan un tratamiento más eficaz y tolerable para la fibromialgia y otras enfermedades de dolor crónico.
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