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¿Cuál es el papel del Sistema Endocannabinoide en el manejo del dolor?

¿Cuál es el papel del Sistema Endocannabinoide en el manejo del dolor? El sistema endocannabinoide desempeña un papel crucial en el tratamiento del dolor al regular la percepción y la respuesta al dolor a través de los receptores CB1 y CB2. Los receptores CB1, ubicados en el cerebro y el sistema nervioso central, ayudan a modular las señales de dolor al reducir la liberación de neurotransmisores excitadores. Los receptores CB2, que se encuentran principalmente en los tejidos periféricos, influyen en la inflamación, que a menudo se asocia con dolor. Los endocannabinoides, como la anandamida y el 2-AG, son producidos por el cuerpo en respuesta a una lesión o inflamación y se unen a estos receptores para aliviar el malestar. La regulación del dolor por parte del sistema endocannabinoide es una parte esencial para mantener la homeostasis y controlar las condiciones de dolor crónico.
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