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How does the molecular weight and size of cannabinoid molecules like CBG and CBN affect their transdermal absorption efficiency?

How does the molecular weight and size of cannabinoid molecules like CBG and CBN affect their transdermal absorption efficiency? The molecular weight and size of cannabinoids like CBG and CBN influence their ability to penetrate the skin barrier, with smaller molecules typically absorbing more efficiently. Larger molecules face more resistance due to the stratum corneum’s lipid-rich structure, requiring enhancers or solubilizing agents for better absorption. Cannabinoids with smaller molecular sizes are more likely to diffuse through the skin layers more easily, achieving faster and more effective delivery. As a result, the molecular weight and size directly impact the absorption rate and bioavailability of cannabinoids in transdermal applications.

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