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How does the skin's varying permeability across different body areas affect the efficacy of cannabinoid delivery via CBD patches?

How does the skin's varying permeability across different body areas affect the efficacy of cannabinoid delivery via CBD patches? The skin’s permeability varies by area, with regions like the palms and soles having thicker, more resistant skin, while areas like the forearm or inner wrist are more permeable. These variations affect how cannabinoids are absorbed through the skin, potentially altering the efficacy of CBD patches. Patches applied to more permeable areas may achieve faster absorption and higher bioavailability. Tailoring patch placement based on skin permeability can optimize therapeutic outcomes for specific conditions.

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