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What factors influence the metabolism of cannabinoids in the human body?

What factors influence the metabolism of cannabinoids in the human body? Several factors influence the metabolism of cannabinoids in the human body, including genetic variations, age, sex, and the presence of other substances. Genetic polymorphisms in cytochrome P450 enzymes, which play a crucial role in cannabinoid metabolism, can lead to differences in how individuals process cannabinoids. Additionally, age and sex can affect metabolic rates, influencing cannabinoid efficacy and safety. The presence of other medications or substances can also lead to drug interactions that modify cannabinoid metabolism. Understanding these factors is essential for optimizing cannabinoid therapies and developing personalized treatment strategies (Wilkinson et al., 2020).
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