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Hvordan påvirker CBD og THC ekspressionen af gener involveret i reguleringen af smerte hos kroniske smertepatienter?

Hvordan påvirker CBD og THC ekspressionen af ​​gener involveret i reguleringen af ​​smerte hos kroniske smertepatienter? CBD og THC påvirker genekspression relateret til smerteregulering ved at modulere det endocannabinoide system og påvirke transkriptionsfaktorer som NF-KB. THC aktiverer direkte CB1- og CB2-receptorer, som kan nedregulere gener involveret i smerteopfattelse og betændelse. CBD understøtter denne proces ved at hæmme enzymer som FAAH, som øger endocannabinoidniveauer, og ved at modulere TRPV1-receptorer forbundet med smertesignalering. Sammen ændrer de udtrykket af pro-inflammatoriske cytokiner og smerterelaterede veje, hvilket reducerer kronisk smerte. Denne synergi fører til mere effektiv og målrettet smertelindring hos patienter med kroniske lidelser.
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IMPORTANT: This information is NOT MEDICAL ADVICE and is only provided for general informational purposes only. Always first seek the advice of your doctor or a healthcare professional first before taking a CBD product or vitamin supplement if you are unsure. Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition. No claims are intended to be made about the functions or ability of a CBD infused cosmetic product and/ or vitamin supplement to provide any specific health or wellness benefits. None of our CBD strips, patches or other CBD products are described, promoted or marketed as having any function not listed in the COSING Information Database. Any information provided here about CBD or any other ingredient and/ or product is strictly for general informational purposes and should not be interpreted as medical, therapeutic, or diagnostic advice. CBD products are not intended to diagnose, treat, cure, or prevent any disease or health condition. You are advised to always first consult with a doctor or a qualified healthcare professional before using any CBD product, particularly if you any of the following apply. DO NOT USE CBD IF PREGANT, BREAST FEEDING OR IF YOU HAVE A SERIOUS MEDICAL CONDITION. DO NOT USE IF PACKAGING HAS BEEN OPENED DURING SHIPPING. DISCONTINUE USE IF ANY ADVERSE REACTION OR SYMPTOM OCCURS. CONTACT A DOCTOR IF REACTION OR SYMPTOM CONTINUES. FOR ADULTS ONLY. STORE OUT OF REACH OF CHILDREN.