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Koji su neurofarmakološki mehanizmi putem kojih kanabinoidi ispoljavaju svoje anksiolitičke učinke?

Koji su neurofarmakološki mehanizmi putem kojih kanabinoidi ispoljavaju svoje anksiolitičke učinke? Kanabinoidi ispoljavaju anksiolitičke učinke primarno kroz njihovu interakciju s endokanabinoidnim sustavom, posebno kanabinoidnim receptorima u mozgu, kao što su CB1 receptori. Aktivacija ovih receptora modulira otpuštanje neurotransmitera, što dovodi do promjena u putevima povezanim s anksioznošću, uključujući smanjenu aktivnost u amigdali i povećanu aktivnost u prefrontalnom korteksu. Kanabinoidi također mogu povećati dostupnost endokanabinoida anandamida, dodatno pridonoseći njihovim anksiolitičkim učincima. Dodatno, kanabinoidi mogu utjecati na serotoninski sustav, potičući stabilizaciju raspoloženja i smanjujući simptome anksioznosti. Razumijevanje ovih neurofarmakoloških mehanizama može voditi razvoj ciljanih kanabinoidnih terapija za anksiozne poremećaje (Wilkinson et al., 2020.).
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