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Comment le CBD affecte-t-il la pharmacocinétique du THC lorsque les deux sont administrés ensemble dans le cadre d’un traitement à long terme de la douleur chronique ?

Comment le CBD affecte-t-il la pharmacocinétique du THC lorsque les deux sont administrés ensemble dans le cadre d’un traitement à long terme de la douleur chronique ? Le CBD modifie le métabolisme du THC en inhibant des enzymes comme le CYP3A4 et le CYP2C9, prolongeant ainsi les effets du THC et réduisant sa concentration plasmatique maximale. Cette interaction stabilise les niveaux de THC, réduisant ainsi les effets secondaires psychoactifs tout en maintenant l’efficacité analgésique. Au fil du temps, la combinaison permet un soulagement constant de la douleur avec des doses de THC plus faibles. Le CBD contrecarre également le développement de la tolérance au THC, rendant le traitement à long terme plus durable. Ensemble, ils améliorent les résultats thérapeutiques pour la gestion de la douleur chronique.
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