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How can the interaction of cannabinoids in transdermal patches with different skin proteins enhance or inhibit their delivery and efficacy?

How can the interaction of cannabinoids in transdermal patches with different skin proteins enhance or inhibit their delivery and efficacy? Cannabinoids may interact with proteins in the skin, such as keratin or collagen, which can either enhance or inhibit their absorption. For example, cannabinoids may bind to specific receptors on skin cells that promote their entry into deeper layers. Alternatively, certain proteins may form barriers that hinder absorption. Understanding these interactions allows formulators to design patches that optimize cannabinoid delivery while minimizing resistance from the skin's natural proteins.

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