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How do cannabinoid interactions with different skin layers (epidermis, dermis, hypodermis) impact the overall effectiveness of CBD patches?

How do cannabinoid interactions with different skin layers (epidermis, dermis, hypodermis) impact the overall effectiveness of CBD patches? Cannabinoids primarily interact with the epidermis and dermis, where they are absorbed and may exert localized effects on pain, inflammation, or skin health. The hypodermis, being deeper, is less relevant for the primary absorption of cannabinoids but may be involved in the systemic effects if cannabinoids penetrate deeper. The permeability of these layers influences how well cannabinoids are absorbed and how effective the patch is at delivering therapeutic benefits. Efficient delivery across these layers is critical for maximizing the patch's effectiveness.

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